Twinrix is a safe and effective combination vaccine used to prevent both Hepatitis A and Hepatitis B virus infections. It works by inducing antibody formation to protect the liver from acute and chronic infections.

Benefits of TWINRIX
This vaccine helps prevent acute liver infection caused by Hepatitis A virus, which is transmitted through contaminated food or water (fecal–oral route), and chronic liver damage caused by Hepatitis B virus, which is transmitted through body fluids, sexual contact, or shared needles (including tattoo needles).

The incubation period of Hepatitis A is approximately 28 days. Symptoms may include fever, loss of appetite, nausea, abdominal pain, jaundice (yellowing of the skin), and dark-colored urine.

In children under 6 years of age, infection is often asymptomatic. However, 10–15% of children may experience prolonged symptoms lasting up to 6 months.

Hepatitis B infection may present with decreased appetite, fever, nausea, vomiting, jaundice affecting the skin and eyes (sclera), dark urine, and abdominal pain.

Approximately 90% of children under 6 years infected with Hepatitis A show no symptoms, despite experiencing acute liver damage. Each year, Hepatitis A accounts for significant mortality in adults, particularly in the elderly (>65 years).

Chronic Hepatitis B infection can lead to chronic liver disease, liver cirrhosis, and liver cancer.

TWINRIX Vaccination Schedule
Children
2 doses administered at 2–15 years of age

Interval: 6–12 months
Adults (>15 years):
3 doses administered at 0, 1, and 6 months

Elderly:
3 doses administered at 0, 1, and 6 months

Compotition of TWINRIX
Each 1 ml dose contains:
• Inactivated Hepatitis A virus
• 720 ELISA units of Hepatitis A antigen
• Hepatitis B surface antigen (HBsAg) 20 mcg

Side Effect of TWINRIX
• Headache
• Nausea
• Vomiting
• Diarrhea
• Pain, swelling, and redness at the injection site

Contraindication of TWINRIX
• Hypersensitivity to any vaccine component
• History of severe allergic reaction to Twinrix, monovalent Hepatitis A, or monovalent
• Hepatitis B vaccines